Route 53 is a feature which can be accessed by hovering over the Town tab, which is at the top of every page, and then selecting Route 53.
Route 53 gives access to three areas; the Honeytree, Honeycombs and MooMoo Ranch.
HoneytreeHoney to try and lure a wild Pokémon so that you can capture it.
You should check the Honey Tree often to see if any Pokémon are eating your honey. You can set an hourly reminder by going to Misc Settings under the Settings tab in order to receive an hourly notification reminding you to check the Honey Tree.
Once a Pokémon appears, you have the option to throw a Pokéball, Greatball, Ultraball or to scare the Pokémon away. Pokeballs can be bought via the Item Shop. Each time you throw a ball it will be used and will not return to your item bag. You can hover above the image of the pokeball to see how many you currently have in your bag. If a Pokémon is left undisturbed at the Honey Tree for too long, it may eat all the honey.
The Pokémon currently obtainable at the Honeytree include Munchlax, Wurmple, Heracross, Aipom, Combee, Cherubi, Teddirusa, Pachirisu, Cubchoo, Budew, Burmy (Plant Cloak), the event Pokémon Slowyore and the legendary Pokémon Celebi.
HoneycombsHoney may be produced.
When you enter the Honeycombs, you are given the option to leave a Male Combee there. If you leave a Combee at the Honeycombs, it will eventually produce Honey which can be claimed every once in awhile.
If you leave Shiny Combees at the Honneycombs there is a chance of them producing Super Honey which can also be used at the Honey Tree.
There is also the possibility of building more Honeycombs, to get space for more Combee. The maximum number of Honeycombs you can have is 3.
MooMoo RanchMooMoo Milk is produced.
MooMoo Milk is obtained through 'milking' the Miltank left there, through the item Milker, which can be obtained at the item shop for 2000 Pokedollar. Also, the Miltank can be 'milked' more than once.
Once you enter MooMoo Ranch, you are given an option to leave a Miltank there. If you leave a Miltank, it may produce MooMoo Milk. MooMoo Milk is used in cooking which can be accessed in your Berrygarden
For a Miltank to produce MooMoo Milk, you have to leave enough berries at the ranch. They will happily accept any berry. However, if all the berries at the ranch have been depleted, your Miltanks will stop producing MooMoo Milk until you replenish the stocks.